The Australian version of the game has no multiplayer mode at all, which has been the subject of much criticism. The PSP version is virtually identical in terms of multiplayer functions.

There are three different online multiplayer modes available.

The uniforms for the Allies are 'Ranger's 2nd', 'Ranger's 4th', and 'Ranger's 5th', whereas the Axis uniforms are simply 'Axis Rookie', 'Axis Regular', and 'Axis Elite'. The Wii version of the game features up to 32 players in one server, with six maps and six uniforms, three for Axis and three for Allies. There, he discovers a terrifying weapon that could potentially shift the war in Germany's favor, and endeavors to thwart Hitler's plans to produce that weapon. Berg is deployed to Northern France in the midst of the Normandy D-Day amphibious invasion to conduct investigations into the German special weapon programs situated in the area. The game has eight missions (seven in the PSP version) and is set against the backdrop of the Battle of Cherbourg. The player takes the role of Office of Strategic Services operative Lieutenant John Berg. This is the second Medal of Honor game to be released for the Wii (the first being Medal of Honor: Vanguard). Medal of Honor: Heroes 2 is set in World War II, starting on the Normandy beaches trying to control German bunkers and then move on to secure a village in France.

The Wii version was announced at Nintendo's E3 2007 Press Conference on July 11, 2007. Each version was built from the ground up for its respective system. It is the 12th installment in the long-running Medal of Honor series of World War II games. Medal of Honor Heroes 2 is a first-person shooter video game for the Wii and the PlayStation Portable.

Download Medal of Honor: Heroes 2